Aiming to overcome this problem Condensyl is based on indirect antioxidants (no risk of reductive stress) and therefore can be taken also without engaging in the above complex testing, which remains however recommended. Support with Condensyl can restore the damaged sperm indexes and, if the female partner is normo-ovulating, can lift up the success rate of IUI close to that of IVF and ICSI. In addition, Condensyl can greatly increase the chances of success of IUI also in subjects not exerting evident signs of sperm oxidative damages.
The alternative techniques, IVF and even more ICSI, may be of help to increase the chances of fertilization but are not able to render good an ejaculate that was of low quality.
In the case of IVF, where fertilization is obtained merging in the same tube an aliquot of semen together with one or more oocytes, there is still some natural competition among several million sperms, which increases the chances to fertilise with the best one. This is paid with a fertilization rate somehow lower than that resulting from ICSI.
In the case of ICSI, the fertilising sperm is selected by the embryologist in the lack of any natural selection only based on morphology. The issue of sperm quality gets minimized by sperm selection techniques intended to screen the ejaculate so to obtain a fraction enriched of potentially good cells. Thereafter, the final selection is again based on morphological criteria.
The fertilization rates are very good and almost always ICSI results in the generation of some embryos. The problem is that sperm selection techniques do not select based on oxidative damage so that a well-looking sperm from the good fraction may still harbor a serious oxidative damage, which may affect the viability of the embryo that was generated. Criticisms to the ICSI technique refer to it as a fertilization “forced” with sperm cells that natural selection would have certainly avoided.
These concerns are further relevant because, with good reasons, ICSI is considered the elective method in case of serious male infertility. Thus, assumed that in some couples ICSI is necessary, it is always advisable to include an effective support to spermatogenesis so to further minimise the problem.